Which of the following is NOT a potential consequence of slow biotransformation of a local anesthetic?

When considering the potential consequences of slow biotransformation of a local anesthetic, it is essential to understand the role of metabolism in the pharmacokinetics of these agents. Slow biotransformation generally leads to a longer duration of action, rather than a reduced duration. This occurs because if a drug is metabolized slowly, it remains active in the body for a longer period, which can lead to prolonged effects and potentially increase the risk of toxicity.

In terms of safety, slow metabolism could indeed amplify the risk of overdose, since the drug concentration may build up in the system without being adequately cleared. Additionally, this accumulation can lead to more severe side effects, particularly if the local anesthetic is cardiotoxic or neurotoxic. Overall, slow biotransformation is more likely to be associated with heightened risk rather than diminished effects, making the indication that it results in a reduced duration of action incorrect.