What is tachyphylaxis?

Tachyphylaxis refers to a phenomenon where there is a rapidly decreasing response to a drug following its repeated administration over a short period. In the context of pharmacology, particularly regarding local anesthetics, it signifies that continuous exposure to the same drug can lead to decreased efficacy, causing the drug to have a lesser effect than initially observed. This is especially critical for practitioners to recognize, as it can impact the management of anesthesia during surgical procedures when the anesthetic might need to be readministered.

The correct choice reflects the essence of this concept, highlighting how increased tolerance can develop due to the cumulative or sustained administration of the drug. Understanding tachyphylaxis can guide practitioners in adjusting dosages or considering alternative agents to maintain effective anesthesia during medical procedures.